Magnetic Resonance Imaging Confirmed Olfactory Bulb Reduction in Long COVID-19: Literature Review and Case Series

• DOI: 10.3390/brainsci12040430
• Publication Date: 2022-03-25T04:05:18Z
• Authors: Andrea Frosolini; Daniela Parrino; Cristoforo Fabbris; Francesco Fantin; Ingrid Inches; Sara Invitto; Giacomo Spinato; Cosimo Filippis
• Keywords: 2019-20 coronavirus outbreak

An altered sense of smell and taste was recognized as one the most characteristic symptoms coronavirus infection disease (COVID-19). Despite patients experiencing a complete functional resolution, there is 21.3% prevalence persistent alteration at 12 months after infection. To date, magnetic resonance imaging (MRI) findings in these have been variable not clearly defined. We aimed to clarify radiological alterations olfactory pathways with long COVID-19 characterized by dysfunction. A comprehensive review English literature performed analyzing relevant papers about this topic. case series presented: all underwent otorhinolaryngology evaluation including Sniffin’ Sticks battery test. previous diagnosis SARS-CoV-2 confirmed positive swabs. The MRIs were acquired using 3.0T MR scanner standardized protocol for tract analysis. Images first analysed dedicated neuroradiologist subsequently reviewed compared available MRIs. retrieved 25 studies; cases dysfunction more than 3 showed bulb (OB) reduction. Patients personal had asymmetry reduction volume OB. This evidence strengthened comparison MRI, where OBs normal. results preliminarily OB an smell. Further studies are needed epidemiology, pathophysiology prognosis.