Temporal Dynamics of Adverse Effects across Five Sessions of Transcranial Direct Current Stimulation

• DOI: 10.3390/brainsci14050457
• Publication Date: 2024-05-03T12:02:22Z
• Authors: Miguel Delicado-M...; Laura Flix-Diez; Francisco Gurdiel...; Enrique Velasco; María Galán-Calle; Sergio Lerma Lara
• Keywords: Transcranial Direct Current Stimulation; Blinding

(1) Background: Transcranial direct current stimulation (tDCS) is a safe intervention, only producing mild and transient adverse effects (AEs). However, there no detailed analysis of the pattern in an application transferable to clinic. Therefore, our objective describe AEs produced by tDCS its temporal evolution. (2) Methods: A total 33 young volunteers were randomized into or sham group. Participants performed hand dexterity task while receiving intervention (20 min 1 mA), for five consecutive days. assessed daily after each classified as somatosensory, pain, other effects. (3) Results: The number was generally increased intervention. Specifically, led more frequent somatosensory discomfort, characterized sensations like itching tingling, alongside painful such burning, compared Additionally, certain events, including neck arm well dizziness blurry vision, exclusive Interestingly, similar across days; meanwhile, group showed trend decrease. (4) Conclusions: produces temporary pain during sessions. different evolution between protocol could unmask blinding most used studies. Potential solutions improving protocols future studies are discussed.