Exploring the Association between Cathepsin B and Parkinson’s Disease

• DOI: 10.3390/brainsci14050482
• Publication Date: 2024-05-10T07:21:04Z
• Authors: Changhao Lu; Xinyi Cai; Shilin Zhi; Xiaofen Wen; Jiaxin Shen; Tommaso Ercoli; Elena Rita Simula; Carla Masala; Leonardo A. Sechi; Paolo Solla
• Keywords: Mendelian Randomization; Genome-wide Association Study

Objective: The aim of this study is to investigate the association between Cathepsin B and Parkinson’s Disease (PD), with a particular focus on determining role N-acetylaspartate as potential mediator. Methods: We used summary-level data from Genome-Wide Association Studies (GWAS) for two-sample Mendelian randomization (MR) analysis, exploring (3301 cases) PD (4681 cases). A sequential two-step MR approach was applied (8148 N-acetylaspartate. Results: analysis yielded that genetically predicted elevated levels correlated reduced risk developing (p = 0.0133, OR: 0.9171, 95% CI: 0.8563–0.9821). On other hand, provided insufficient evidence determine affected 0.8567, 1.0035, 0.9666–1.0418). estimated effect in process 7.52% (95% CI −3.65% 18.69%). Conclusions: This suggested decreased PD, mediation Further research needed better understand relationship.