Venous Resection During Pancreatoduodenectomy for Pancreatic Ductal Adenocarcinoma—A Multicentre Propensity Score Matching Analysis of the Recurrence After Whipple’s (RAW) Study

• DOI: 10.3390/cancers17071223
• Publication Date: 2025-04-04T15:31:00Z
• Authors: Ruben Bellotti; Somaiah Aroori; Benno Cardini; Florian Ponholzer; Thomas B. Russell; Peter L. Labib; Stefan Schneeberger; Fabio Ausania; Elizabeth Pando; Keith J. Roberts; Ambareen Kausar; Vasileios K. Mavr...; Gabriele Marangoni; Sarah C. Thomasset; Adam E. Frampton; Pavlos Lykoudis; Nassir Alhaboob; Hassaan Bari; Andrew M. Smith; Duncan Spalding; Parthi Srinivasan; Brian R. Davidson; Ricky H. Bhogal; Daniel Croagh; Ismael Dominguez; Rohan Thakkar; Dhanny Gomez; Michael A. Silva; Pierfrancesco Lap...; Andrea Mingoli; Alberto Porcu; Nehal S. Shah; Zaed Z. R. Hamady; Bilal Al-Sarrieh; Alejandro Serrablo; ; Manuel Maglione

Background: Pancreatoduodenectomy with venous resection (PDVR) may be performed to achieve tumour clearance in patients with a pancreatic ductal adenocarcinoma (PDAC) with venous involvement. This study aimed to evaluate the impact of PDVR on PDAC outcomes. Methods: In total, 435 PDAC patients with either R0 status (n = 322) or R1 status within the superior mesenteric vein groove (n = 113) were extracted from the Recurrence After Whipple’s (RAW) study dataset. PDVR patients were matched in a 1:2 ratio with standard PD patients. Comparisons were then made between the two groups (surgical radicality and survival). Results: A total of 81 PDVRs were matched with 162 PDs. Neoadjuvant chemotherapy (5.7% vs. 13.6%, p = 0.032) and R1 resection rates (17.9% vs. 42%, p < 0.001) were higher in the PDVR group. Risk factors for R1 resection included venous resection (p < 0.001 for sleeve and p = 0.034 for segmental resection), pT3 (p = 0.007), and pN1 stage (p = 0.045). PDVR patients had lower median overall survival (OS, 21 vs. 30 months (m), p = 0.023) and disease-free survival (DFS, 17 m vs. 24 m, p = 0.043). Among PDVR patients, R status did not impact on OS (R0: 23 m, R1: 21 m, p = 0.928) or DFS (R0: 18 m, R1: 17 m, p = 0.558). Irrespective of R status, systemic recurrence was higher in the PDVR group (p = 0.034). Conclusions: Independent of R status, the PDVR group had lower overall survival and higher systemic recurrence rates.