Evaluation of Chitotriosidase and Neopterin as Biomarkers of Microvascular Complications in Patients with Type 1 Diabetes Mellitus

• DOI: 10.3390/diagnostics11020263
• Publication Date: 2021-02-09T09:18:50Z
• Authors: Ancuța Cutaș; Cristina Drugan; Gabriela Roman; Adriana Rusu; Cristina Sorina C...; Andrei Achimaș-Ca...; Tudor Drugan
• Keywords: Neopterin; Microalbuminuria; Endothelial Dysfunction

The chronic complications of diabetes mellitus (DM) are accompanied by inflammatory manifestations. Our study aimed to evaluate a possible association between the status (reflected serum chitotriosidase and neopterin) timely evolution occurrence microvascular in patients with type 1 DM. This observational, cross-sectional included 82 DM from Centre for Diabetes, Nutrition Metabolic Diseases, Cluj-Napoca, Romania. results demonstrated link extent inflammation, evaluated enzymatic activity circulating chitotriosidase, onset complications, especially diabetic neuropathy retinopathy. Chitotriosidase showed an ascending over time. In non-smoking patients, increase was correlated microalbuminuria decline glomerular filtration rate, while smokers, only presence positive correlation disease progression noticed. According our results, time span moment diagnosis longer non-smokers than smokers. These also imply that increased may be predictor endothelial dysfunction