Thromboelastometry in Neonates with Respiratory Distress Syndrome: A Pilot Study

• DOI: 10.3390/diagnostics11111995
• Publication Date: 2021-10-28T02:00:23Z
• Authors: Georgios N. Katsaras; Rozeta Sokou; Andreas G. Tsantes; Aikaterini Konsta...; Dimitra Gialamprinou; Daniele Piovani; Stefanos Bonovas; Anastasios G. Kri...; Georgios Mitsiakos; Styliani Kokoris; Argirios E. Tsantes
• Keywords: Thromboelastometry; Clotting time

Although respiratory distress syndrome (RDS) constitutes a postnatal risk factor for bleeding and thromboembolic events in neonates, few studies have addressed this issue. We aimed to evaluate the hemostatic profile of neonates with RDS using rotational thromboelastometry (ROTEM).An observational study was conducted from November 2018 2020 NICU General Hospital Nikaia "Aghios Panteleimon". Preterm term hospitalized were included EXTEM (tissue factor-triggered extrinsic pathway), INTEM (ellagic acid activated intrinsic FIBTEM (with platelet inhibitor cytochalasin D) assays performed at onset disease.A hypocoagulable noted compared controls, expressed as significant prolongation CT (clotting time) CFT (clot formation time), lower A10 (amplitude 10 min), MCF (maximum clot firmness), LI60 (lysis index). Furthermore, CT, decreased found RDS. Multivariable logistic regression analysis showed that is an independent recorded alterations ROTEM variables.RDS associated greater hyperfibrinolytic potential healthy neonates.