Is Primary HPV with Secondary p16/Ki67 Dual-Stain an Alternative HSIL-Risk Detection Strategy in Cervical Cancer Screening for Women under 30 Years?

• DOI: 10.3390/diagnostics11112012
• Publication Date: 2021-11-02T02:21:08Z
• Authors: Martyna Trzeszcz; Maciej Mazurec; Robert Jach; Karolina Mazurec; Zofia Jach; Izabela Kotkowska...; Magdalena Kania; Mariola Wantuchowicz; Anna Prokopyk; Piotr Barcikowski; Marcin Przybylski; Joanna Wach; Agnieszka Halon
• Keywords: Triage; Squamous intraepithelial lesion

Recently, cervical cancer rates elevation has been noted in women aged 20-39 years regions with a very high human development index (HDI). The onset of is observed the age range 25-29 years, which should necessitate effective precancer screening younger groups, including those <25 years. From 30.066 liquid-based tests results (n = 30.066), 3849 cytology, 1321 high-risk papillomavirus (HRHPV) and 316 p16/Ki67 performed <30 were selected. Performance characteristics calculated for three models: primary HRHPV triage, cytology reflex HPV alone. Primary triage was significantly more sensitive high-grade squamous intraepithelial lesion quantified neoplasia grade 2 or worse [HSIL(CIN2+)] detection than alone (83.3% vs. 70.8%/45.8%) had higher diagnostic predictive values (PPV:29.4%/21.3%/22.9%; NPV:91.7%/82.9%/82.2%, respectively at CIN2+ threshold). number colposcopies per HSIL(CIN2+) indices 3.4, 4.7 4.4, respectively. testing HPV-positive cases might be an strategy superior performance when compared cytology-based models. Women also benefit from introduction to approach.