mTOR Pathway Substrates Present High Activation in Vascular Malformations and Significantly Decrease with Age

• DOI: 10.3390/diagnostics14010038
• Publication Date: 2023-12-25T08:42:12Z
• Authors: Jakub Kopeć; Elżbieta Sałacińs...; Magdalena Orzecho...; Monika Sokolnicka; Aleksandra Gawłow...; Przewratil Przemy...
• Keywords: vascular anomalies; Medicine (General); 03 medical and health sciences; sirolimus; R5-920; 0302 clinical medicine; lymphatic malformation; venus malformation; rapamycin; mTOR; Article

Vascular anomalies often result in aesthetic flaws, pain, and impair the quality of life. They require challenging treatments that frequently do not provide desired results. The mammalian target rapamycin (mTOR) is directly involved development these malformations. However, exact mechanism behind mTOR dysregulation has been unambiguously defined. purpose this study to investigate activation selected substrates partially assess its involvement disease process.