Saliva as a Biological Fluid in SARS-CoV-2 Detection

• DOI: 10.3390/diagnostics14090922
• Publication Date: 2024-05-02T15:39:42Z
• Authors: Emily Thalia Teix...; Fabiana Barcelos ...; Rosana Antunes da...; Karen Ingrid Tasca; Cristiane Nonato ...; Amanda Thais Godoy; Leonardo Nazario ...; Michelle Venancio...; Camila Gonçalves ...; Rafael Plana Simões; Agatha Mayume Sil...; Carlos Magno Cast...; Maria Cristina Pe...; Guilherme Targino...; Rejane Maria Tomm...
• Keywords: Biological fluids; 2019-20 coronavirus outbreak

The polymerase chain reaction of upper respiratory tract swab samples was established as the gold standard procedure for diagnosing SARS-CoV-2 during COVID pandemic. However, saliva collection has attracted attention an alternative diagnostic method. goal this study to compare use and nasopharyngeal (NPS) detection SARS-CoV-2. Ninety-nine paired were evaluated by a qualitative diagnosis quantitative comparison viral particles. Furthermore, limits each sample technique determined. cycle threshold (CT) values samples, vaccination status, financial costs associated with compared. results showed equivalence in (96.96%) comparing collection, although there low agreement. limit test demonstrated both methods. We did not observe statistically significant association between CT indicating that vaccine had no influence on load at diagnosis. Finally, we observed incurs lower requires less plastic materials, making it more sustainable. These findings support adoption feasible sustainable COVID-19.