Association between Clinical Use of Colchicine and Risk of Type 2 Diabetes Mellitus among Gouty Patients: A Nationwide Cohort Study

• DOI: 10.3390/ijerph19063395
• Publication Date: 2022-03-15T07:06:10Z
• Authors: Chen-Chih Chu; Yong-Chen Chen; Ming-Hsun Lin; Wen-Tung Wu; Feng-Cheng Liu; Hsiang-Cheng Chen; Yu-Ching Chou; Chien-An Sun
• Keywords: Colchicine

Gout is the most common form of inflammatory arthritis in adults. Even though a link between gouty and type 2 diabetes mellitus (T2DM) has been reported, there limited understanding association anti-inflammatory agent colchicine risk T2DM. This aim this study was to assess use T2DM an Asian cohort. A retrospective cohort conducted using National Health Insurance Research Database (NHIRD) Taiwan from 2000 2013. The cohorts comprised 3841 patients (the exposed cohort) 7682 not unexposed -cohort). primary outcome incident DM. hazard ratios (HRs) 95% confidence intervals (CIs) derived Cox proportional regression model were used diabetes. cumulative incidence significantly lower (18.8%) than (25.0%). users non-users (adjusted HR, 0.74; CI, 0.36-0.87). inverse relationship remained consistent across sex age groups. provides longitudinal evidence that associated with reduced conclusion, however, needs be interpreted cautiously given lack body mass index data NHIRD. Further studies are needed determine clinical implications study.