The Intersection of HIV and Pulmonary Vascular Health: From HIV Evolution to Vascular Cell Types to Disease Mechanisms

• DOI: 10.3390/jvd3020015
• Publication Date: 2024-05-06T19:09:36Z
• Authors: Amanda K. Garcia; Sharilyn Almodovar
• Keywords: 0301 basic medicine; viral evolution; 03 medical and health sciences; Nef; SMC; RC666-701; HIV; Diseases of the circulatory (Cardiovascular) system; endothelial cells; Article; smooth muscle cells

People living with HIV (PLWH) face a growing burden of chronic diseases, owing to the combinations aging, environmental triggers, lifestyle choices, and virus-induced inflammation. The rising incidence pulmonary vascular diseases represents major concern for PLWH. study HIV-associated complications ideally requires strong understanding cell biology pathogenesis at molecular level effective applications in infectious medicine. Active infection and/or proteins disturb delicate balance between tone constriction, which is pivotal maintaining health. One defining features its high genetic diversity several factors including mutation rate, recombination viral strains, immune selective pressures, or even geographical factors. intrinsic has important implications pathogenic outcomes overall battle combat HIV. Challenges field present themselves from two sides same coin: those imposed by virus itself stemming host. may be advanced further developing vivo vitro models that are well described both mechanistic studies. In essence, multidisciplinary approach, drawing upon insights this review article, we discuss fundamentals virology their impact on disease, aiming enhance either area simultaneously. Bridging gap preclinical research findings clinical practice essential improving patient care. Addressing these knowledge gaps interdisciplinary collaborations, innovative approaches, dedicated efforts prioritize HIV-related global agenda.