Synthesis and In Vitro Antibacterial Evaluation of Mannich Base Nitrothiazole Derivatives

• DOI: 10.3390/m1793
• Publication Date: 2024-03-18T12:17:29Z
• Authors: Phelelisiwe S. Dube; Dylan Hart; Lesetja J. Legoabe; Audrey Jordaan; Digby F. Warner; Richard M. Beteck
• Keywords: Mannich base; Base (topology)

Nitrothiazole derivatives have been reported to exhibit activity against aerobic, anaerobic, and microaerophilic bacteria. This profile makes the nitrothiazole compound class an ideal lead source Mycobacterium tuberculosis, which flourishes in varied environments with different oxygen concentrations. In this work, we investigated six for antitubercular activity. The compounds exhibited potent activity, 9 10 possessing equipotent MIC90 value of 0.24 µM. were cytotoxicity HEK293 cells hemolysis red blood cells, they demonstrated no nor hemolytic effects, suggesting possess inherent