The Infant-Derived Bifidobacterium bifidum Strain CNCM I-4319 Strengthens Gut Functionality

• DOI: 10.3390/microorganisms8091313
• Publication Date: 2020-08-28T13:17:08Z
• Authors: Rebeca Martín; Francesca Bottacini; Muireann Egan; Celia Chamignon; Valérie Tondereau; Raphaël Moriez; Jan Knol; Philippe Langella; Hélène Eutamene; Tamara Smokvina; Douwe van Sinderen
• Keywords: Bifidobacterium bifidum; Human gastrointestinal tract; Strain (injury)

Bifidobacteria are among the first colonisers of gastrointestinal tract breast-fed newborns due to, other things, their ability to metabolise oligosaccharides naturally occurring in human milk. The presence bifidobacteria infant gut has been shown promote intestinal health and homeostasis as well preserve a functional barrier, thus positively influencing host well-being. Among human-associated commensals, Bifidobacterium bifidum described only species capable extracellular degradation both mucin-type glycans HMOs, thereby giving this special role commensal forager diet-derived glycans. In present study, we assess possible beneficial properties probiotic potential B. strain CNCM I-4319. silico genome analysis growth experiments confirmed expected consume HMOs mucin. By employing various animal models, were also able I-4319 integrity functionality from stress-induced inflammatory damage, enforcing its an effective strain.