Pilot Study on the Forehead Skin Microbiome and Short Chain Fatty Acids Depending on the SC Functional Index in Korean Cohorts

• DOI: 10.3390/microorganisms9112216
• Publication Date: 2021-10-26T01:42:05Z
• Authors: Haryung Park; Karina Arellano; Yuri Lee; Subin Yeo; Yosep Ji; Joontae Ko; Wilhelm Holzapfel
• Keywords: Transepidermal water loss; Dry skin; Barrier function; Propionibacterium Acnes

Dry skin is one of the indicators a compromised barrier. An intact barrier not only important to reserve hydration within epidermal tissue but also protect our from environmental stressors and inhibit pathogen invasion; damage may lead inflammatory diseases. Some microbial metabolites such as short chain fatty acids or destroy harmful bacteria regulate host immune system. The impact microbiome on function was studied in two groups 75 participants each. cohort equally divided dry moist types, based stratum corneum (SC) functionality index (SCFI), reflecting ratio transepidermal water loss (TEWL). A group represents low SCFI high SCFI. Compared with group, propionate Cutibacterium levels (previously known Propionibacterium acnes) were significantly higher (p < 0.001) group. Levels negatively correlated those Staphylococcus 0.0001) both groups. had concentration 0.001). This study showed that community acid be considered significant determinants skin.