A Novel Quercetin Encapsulated Glucose Modified Liposome and Its Brain-Target Antioxidative Neuroprotection Effects

• DOI: 10.3390/molecules29030607
• Publication Date: 2024-01-26T15:54:27Z
• Authors: Jian Chen; Jinxia Chen; Peiyun Yu; Chunyan Yang; Chen Xia; Junlin Deng; Manyou Yu; Zuoya Xiang; Lu Gan; Boyu Zhu; Yong Wu; Xing Yang
• Keywords: Viability assay

Neurodegenerative diseases (NDDs) are mainly induced by oxidative stress which produces excessive reactive oxygen species (ROS). Quercetin (QU) is a potent antioxidant with some effects on NDDs. This study prepared and characterized novel glucose-modified QU liposome (QU–Glu–Lip), aiming not only to overcome QU’s poor water solubility bioavailability but also deliver more brain tissue enhance its neuroprotective effect. QU–Glu–Lip possessed encapsulation efficiency (EE) of 89.9%, homogenous particle sizes (116–124 nm), small PDI value (<0.3), zeta −1.363 ± 0.437 mV, proper pH salt stability, cytotoxicity. The penetrated the blood–brain barrier (BBB) mediated via glucose transporter 1 (GLUT1) was taken neuronal cells efficiently than without glucose, according bEnd.3 PC12 cell tests. attenuated H2O2-induced damage higher viability (88.42%) lower intracellular ROS compared that QU. had target ability delivered cells, effectively exerting antioxidative neuroprotection There potential for application effective treatment