The Subgingival Plaque Microbiome, Systemic Antibodies against Bacteria and Citrullinated Proteins following Periodontal Therapy

• DOI: 10.3390/pathogens10020193
• Publication Date: 2021-02-12T21:12:10Z
• Authors: Emily Davison; William Johnston; Krystyna Piela; Bob T. Rosier; Michael Paterson; Alex Mira; Shauna Culshaw
• Keywords: Aggregatibacter actinomycetemcomitans; Prevotella intermedia; Periodontal pathogen

Periodontitis (PD) shows an association with rheumatoid arthritis (RA) and systemic inflammation. Periodontal pathogens, namely Porphyromonas gingivalis Aggregatibacter actinomycetemcomitans, are proposed to be capable of inducing citrullination peptides in the gingiva, formation anti-citrullinated protein antibodies (ACPAs) within susceptible hosts. Here, we sought investigate whether periodontal treatment influenced inflammation antibody titres P. gingivalis, A. Prevotella intermedia ACPA 42 systemically health patients disease. Subgingival plaque serum samples were collected from study participants before (baseline) 90 days after analyse abundance specific bacteria evaluate anti-bacterial antibodies, C-reactive (CRP), tumour necrosis factor α (TNF-α), interleukin 6 (IL-6) serum. Following treatment, all showed reduced Despite observing a weak positive correlation between CRP IL-6 at baseline, observed no significant reductions any indicators treatment. In contrast, anti-P. IgG significantly post-treatment (p < 0.001, Wilcoxon signed rank test), although changes for other titres. Patients who had detectable subgingival plaques higher titres, suggesting potential colonisation