HTLV-1-Associated Myelopathy (HAM) Incidence in Asymptomatic Carriers and Intermediate Syndrome (IS) Patients

• DOI: 10.3390/pathogens13050403
• Publication Date: 2024-05-14T07:20:29Z
• Authors: Rosa Maria do Nas...; Tatiane Assone; Michel E. Haziot; Jerusa Smid; Victor A. Folgosi; Carolina Rosadas; Jorge Casseb; Augusto C. Penalv...
• Keywords: Asymptomatic carrier

Several studies suggest that HTLV-1 infection may be associated with a wider spectrum of neurological and clinical manifestations do not meet diagnostic criteria for HAM. These conditions later progress to HAM or constitute an intermediate form: syndrome (IS), mid-point between asymptomatic carriers those full myelopathy. Thus, we determined the incidence cases in HTLV-1-asymptomatic IS patients, clinical/laboratory markers. A total 204 HTLV-1-positive patients were included this study, divided into two groups: Group 1, including 145 subjects (ASY), 2, 59 inflammatory symptoms more than three systems high proviral load (PVL). During 60-month follow-up time, age ranging from 47 79 years, ten fifty-nine initially diagnosed as developed (iHAM), initial ASY directly. Women prevalent all groups. For iHAM ranged 20 72 mean 53 (±15 SD). Older was development HAM, higher PVL IS; however, there no any specific symptom sign, risk iHAM. In conclusion, could early phase findings show presence probabilities our cohort previously reported.