Immunogenicity, Pathogenesis, and Host’s Immuno-Responses to Marburg Virus Infection

• DOI: 10.3390/pathogens14040323
• Publication Date: 2025-03-28T08:11:40Z
• Authors: Emmanuel Edwar Si...; Nicaise Ndembi; Ayman Ahmed; Claude Mambo Muvunyi
• Keywords: Marburg virus; Pathogenesis; Viral Pathogenesis; Host response

Due to the sudden emergence and burnout nature of Marburg virus (MARV) outbreaks, little is known about MARV's pathogenicity immunogenicity. These gaps in knowledge are limiting our understanding disease implementation cost-effective prevention control measures including case management through safe effective therapeutic modalities. Therefore, this review aims synthesize summarize evidence pathogenicity, immunogenicity, virulence humans towards MARV. Upon infection, MARV rapidly disseminates throughout various tissues, provoking severe cellular injury, particularly lymphatic organs, liver, kidneys, gastrointestinal tract. The takes advantage host cells by avoiding immune responses, mainly disrupting function dendritic blocking signaling pathways for interferon. As a result, patients experience profound dysregulation characterized early lymphocyte depletion shift pro-inflammatory cytokine release, resulting storm that can lead hemorrhagic septic shock. Additionally, adaptive antibody production, impaired, further complicating recovery increasing susceptibility outcomes. Understanding these intricate host-pathogen interactions critical developing strategies vaccines against Continuing research essential explain mechanisms evasion identify potential intervention points improving patient