Lyophilized Composite Loaded with Meloxicam-Peppermint oil Nanoemulsion for Periodontal Pain

• DOI: 10.3390/polym13142317
• Publication Date: 2021-07-14T14:13:42Z
• Authors: Amal M. Sindi; Khaled M. Hosny; Waleed S. Alharbi
• Keywords: Meloxicam

Maintaining oral health helps to prevent periodontal inflammation and pain, which can progress into more detrimental issues if left untreated. Meloxicam (MX) is a commonly used analgesic for but it have adverse gastrointestinal effects poor solubility. Therefore, this study aimed enhance the solubility of MX by developing self-nanoemulsifying drug delivery system (SNEDDS). Considering anti-ulcer activity peppermint oil (PO), was added in mixture with medium-chain triglyceride (MCT) MX-loaded SNEDDS formulation (MX-PO-SNEDDS). After optimization, MX-PO-SNEDDS exhibited PO:MCT ratio 1.78:1, surfactant HLB value 14, MX:oil mix 1:15, particle size 47 ± 3 nm, stability index 85 4%, ex vivo Jss 4 0.6 μg/cm2min, ulcer 1 0.25 %. Then, orally flash disintegrating lyophilized composites (MX-SNELCs) were prepared using optimized MX-PO-SNEDDs. Results reveal that MX-SNELCs had wetting time s disintegration high vitro release 91% end 60 min. The results pharmacokinetic studies human volunteers further demonstrated that, compared marketed tablets, provided higher Cmax, Tmax, AUC relatively greater bioavailability 152.97 successfully developed found be better alternative than conventional tablet dosage form, thus indicating their potential development clinically acceptable strategy managing pain.