Label-Free Biosensor Based on Particle Plasmon Resonance Coupled with Diffraction Grating Waveguide

• DOI: 10.3390/s24175536
• Publication Date: 2024-08-27T10:19:01Z
• Authors: Wei-Ting Hsu; Yu-Cheng Lin; Huang-Chin Yang; Devesh Barshilia; Po-Liang Chen; Fu-Chun Huang; Lai-Kwan Chau; Wen-Hsin Hsieh; Guo-En Chang
• Keywords: Ultrasonic grating

Particle plasmon resonance (PPR), or localized surface (LSPR), utilizes intrinsic in metal nanoparticles for sensor fabrication. While diffraction grating waveguides monitor bioaffinity adsorption with out-of-plane illumination, integrating them PPR biomolecular detection schemes remains underexplored. This study introduces a label-free biosensing platform waveguide. Gold are immobilized on glass slide contact sample, while UV-assisted embossed is positioned opposite. The setup reflection to detect changes the environment's refractive index, indicating binding at gold nanoparticle surface. positional shift of diffracted beam, measured varying indices sucrose solutions, shows sensitivity 0.97 mm/RIU 8 cm from position-sensitive detector, highlighting enhanced due PPR-diffraction coupling near Furthermore, achieved resolution 3.1 × 10