Solubility of Gallic Acid in Single and Mixed Solvents

• DOI: 10.3390/separations11010036
• Publication Date: 2024-01-22T11:49:31Z
• Authors: Yea-Rok Park; Bong-Seop Lee
• Keywords: Hildebrand solubility parameter

Gallic acid, known for its biological activity contributing to human health, including antioxidant, anti-inflammatory, anticancer, and antimutagenic properties, was the focus of this study. The solubility gallic acid experimentally measured in pure mixed solvents water, ethanol, acetic predicted using COSMO-SAC model Hansen parameter. parameter method a higher water than solvent, it maximum at 80% content, showing different results from experimental data trends. However, molar volume obtained COSMO calculations resulted tendency that matched results. revealed ethanol compared with solvent falling within range between them. Using same method, applied acid/water acid/ethanol mixtures, similar trends were observed data. In particular, mixture exhibited solubility, phenomenon well-predicted. As temperature increased, both also increased. While effectively captured trend, values slightly lower depending on types confirmed by comparing σ-profiles each compound. σ-profile closely resembled result led acid. ethanol/water could be anticipated when two significant differences their are an appropriate ratio.