HBM4EU Chromates Study—Genotoxicity and Oxidative Stress Biomarkers in Workers Exposed to Hexavalent Chromium

• DOI: 10.3390/toxics10080483
• Publication Date: 2022-08-19T06:48:23Z
• Authors: Ana Tavares; Kukka Aimonen; Sophie Ndaw; Aleksandra Fučić; Julia Catalán; Radu Corneliu Duca; Lode Godderis; Bruno C. Gomes; Beata Janasik; Carina Ladeira; Henriqueta Louro; Sónia Namorado; An Van Nieuwenhuyse; Hannu Norppa; Paul T. J. Scheepers; Célia Ventura; Jelle Verdonck; Susana Viegas; Wojciech Wasowicz; Tiina Santonen; Maria João Silva
• Keywords: Hexavalent Chromium; Comet Assay; Malondialdehyde

A study was conducted within the European Human Biomonitoring Initiative (HBM4EU) to characterize occupational exposure Cr(VI). Herein we present results of biomarkers genotoxicity and oxidative stress, including micronucleus analysis in lymphocytes reticulocytes, comet assay whole blood, malondialdehyde 8-oxo-2′-deoxyguanosine urine. Workers from several Cr(VI)-related industrial activities controls (within company) non-industrial (outwith environments were included. The significantly increased (p = 0.03 for MN reticulocytes; p < 0.001 data) stress levels 0.007 MDA 8-OHdG pre-shift urine samples, respectively) that detected exposed workers over outwith company suggest Cr(VI) might still represent a health risk, particularly, chrome painters electrolytic bath platers, despite low Cr exposure. within-company displayed DNA chromosomal damage comparable those group, highlighting relevance considering all industry as potentially exposed. use effect proved their capacity detect early biological effects exposure, contribute identifying subgroups are at higher risk. Overall, this reinforces need further re-evaluation limit better application protection measures. However, it also raised some additional questions unexplained inconsistencies follow-up studies be clarified.