Urinary Phthalate Metabolites and Biomarkers of Oxidative Stress in a Mexican-American Cohort: Variability in Early and Late Pregnancy

• DOI: 10.3390/toxics4010007
• Publication Date: 2016-03-14T15:03:45Z
• Authors: Nina Holland; Karen Huen; Vy Tran; Kelly Street; Brian Nguyen; Asa Bradman; Brenda Eskenazi
• Keywords: Endocrine disruptor

People are exposed to phthalates through their wide use as plasticizers and in personal care products. Many endocrine disruptors have been associated with adverse health outcomes. However, knowledge gaps exist understanding the molecular mechanisms effects of exposure early late pregnancy. In this study, we examined relationship eleven urinary phthalate metabolites isoprostane, an established marker oxidative stress, among pregnant Mexican-American women from agricultural cohort. Isoprostane levels were on average 20% higher at 26 weeks than 13 Urinary metabolite concentrations suggested relatively consistent exposures over The between isoprostane was significant for sum di-2-ethylhexyl high weight exception monobenzyl phthalate, which not stress either time point. contrast, low weeks, but became stronger later pregnancy (p-value = 0.009 metabolites). Our findings suggest that prenatal may influence is obesity other