Inflammatory Biomarkers Interleukin 1 Beta (IL-1β) and Tumour Necrosis Factor Alpha (TNF-α) Are Differentially Elevated in Tobacco Smoke Associated COPD and Biomass Smoke Associated COPD

• DOI: 10.3390/toxics9040072
• Publication Date: 2021-04-01T14:44:01Z
• Authors: Bellipady Shyam P...; Sindaghatta Krish...; Sravan Kumar V; Maheswarappa Mahe...; Biligere Siddaiah...; Komarla Sundarara...; Koustav Ganguly; Padukudru Anand M...
• Keywords: biomass; Chemical technology; tumour necrosis factor α; TP1-1185; Article; 3. Good health; FEV1; 03 medical and health sciences; 0302 clinical medicine; COPD; interleukin 1 β; tobacco smoke

Chronic obstructive pulmonary disease (COPD), the leading cause of mortality and morbidity worldwide, is characterized by abnormal activation inflammatory cells. The increased pro-inflammatory cytokines, such as tumour necrosis factor alpha (TNF-α) interleukin 1 beta (IL-1β), further amplify inflammation. We evaluated dose response relationship IL-1β TNF-α levels severity airflow limitation, differential responses in between biomass COPD (BMS-COPD) tobacco smoke (TS-COPD) using a case control design 160 subjects. Patients with had higher serum both compared to healthy controls. A large difference was observed TS-COPD BMS-COPD, where patients much levels. Serum were BMS-COPD. Levels correlated better limitation than Both negative linear Forced Expiratory Volume 1st second (FEV1) six-minute walk distance. correlations stronger FEV1 St George Respiratory Questionnaire (SGRQ) scores body mass index (BMI) not significant. In conclusion, cytokines are differently elevated respectively.