Common variants APOC3, APOA5, APOE and PON1 are associated with variation in plasma lipoprotein traits in Greenlanders

• DOI: 10.3402/ijch.v66i5.18311
• Publication Date: 2012-04-16T15:59:31Z
• Authors: Piya Lahiry; Matthew R. Ban; Rebecca L. Pollex; Cynthia G. Sawyez; Murray W. Huff; T. Kue Young; Peter Bjerregaard; Robert A. Hegele
• Keywords: Apolipoprotein E

Objectives. We undertook studies of the association between common genomic variations in APOC3, APOA5, APOE and PON1 genes variation biochemical phenotypes a sample Greenlanders.Study Design. Genetic study quantitative lipoprotein traits.Methods. In 1,310 adult Greenlanders, fasting plasma lipid, apolipoprotein (apo) concentrations were assessed for with known functional variants PON1. For significantly associated polymorphisms, between-genotype differences examined closer detail.Results. found that (1) restriction isotype was total LDL cholesterol apo B (all p & .0001); (2) APOC3 promoter genotype triglycerides, HDL A-I .002); (3) APOA5 codon 19 triglycerides (p = .027); (4) 192 .05).Conclusions. Taken together, our results suggest genetic are significant intermediate traits metabolism Greenlanders; associations similar to those observed these other populations.