Evaluation of the Effect of Vitamin E on Reproductive Parameters in Morphine-Treated Male Mice

• DOI: 10.34172/ahj.2023.1415
• Publication Date: 2023-10-14T09:16:35Z
• Authors: Katayoon Arjmand; Erfan Daneshi; Soheila Pourmasumi; Fardin Fathi; Sherko Nasseri; Parvin Sabeti
• Keywords: Malondialdehyde; Narcotic

Background: Morphine is a narcotic pain reliever that prescribed to reduce postoperative and can produce reactive oxygen species (ROS). Therefore, it have negative effects on spermatogenesis male fertility. Vitamin E an effective antioxidant which plays important role in membrane lipid peroxidation due increased ROS. The present study aimed evaluate the of vitamin morphine sperm parameters, level malondialdehyde (MDA), diameter seminiferous tubules morphine-treated mice. Methods: In this experimental study, 80 mice were divided into ten groups (n=8) including control, normal saline, vehicle, morphine, various doses (100, 200, 300 mg/kg), plus mg/kg) groups. followed up for 30 consecutive days. Sperm testis weight, tubules, MDA analyzed compared. Findings: Data analysis showed seminal parameters decreased significantly (excluding count) there was increase compared with saline group (P<0.05). Administration E100 morphinetreated did not show significant difference evaluated group. However, E200 E300 reduced improved (P≤0.05). Conclusion: results co-administration high (200 & 300) could prevent deleterious some reproductive decrease