ANTIBACTERIAL ACTIVITY OF CATIONIC AMPHIPHIL CONJUGATES WITH CIPROFLOXACIN

• DOI: 10.34660/inf.2021.25.98.024
• Publication Date: 2024-12-12T10:23:33Z
• Authors: V.N. Silnikov; L.S. Koroleva; D.A. Zadvornykh
• Keywords: Staphylococcus aureus; antibacterial activity; ciprofloxacin; cationic amphiphiles; Pseudomonas aeruginosa; Enterococcus faecalis; 3. Good health

This article is devoted to the synthesis and primary evaluation of the antibacterial activity in vitro and in vivo of cationic amphiphiles based on quaternary salts of 1,4-diazabicyclo [2.2.2] octane with ciprofloxacin against gramnegative and gram-positive microorganisms. Shown high antibacterial activity in vitro against gram-negative pathogens, moderate against Staphylococcus aureus and low against Enterococcus faecalis. The in vivo activity against Staphylococcus aureus and Pseudomonas aeruginosa was comparable (S. Aureus) or higher (P. Aeruginosa) that of ciprofloxacin. The results obtained indicate the prospects for the design of new antibacterial drugs based on conjugates of antibiotics with synthetic cationic amphiphiles