Identification of Auto and Alloantibodies in Patients with Hereditary Haemolyticanaemia (HHA)

• DOI: 10.36347/sjams.2024.v12i12.012
• Publication Date: 2024-12-16T05:12:56Z
• Authors: Dr. Mansura Khan; Abdullah Al Mamun...; Dr. Sanzida Akter; Dr. Mehraj Mahjab...; Dr. Mohammad Moni...
• Keywords: Identification

Introduction: Hereditary hemolytic anemia (HHA) is a group of rare and varied illnesses caused by anomalies in the metabolism plasma membranes and/or red blood cells (RBCs), which lead to premature lysis or clearance these cells. In Bangladesh, data regarding cell antibodies (allo as well autoantibodies) multiple transfused patients insufficient. Therefore, this study aimed identify auto alloantibodies among with HHA. Methods: This cross-sectional was conducted Department Immunology, BIRDEM Armed Forces Institute Pathology (AFIP), Dhaka Cantonment, Dhaka, Bangladesh for one year period. A total 300 were included HHA according selection criteria. Results: Among patients, majority (35.67%) them age 1-10 years. Of all 186(62%) male, 114(38%) female. Rh positive 96.67% only 10(3.33%) Rh-negative. first transfusion 3.09±4.89 The number units 75.70±89.03. antibody detected 12(4.0%) auto-antibody, alloantibody, both 2(0.67%), 6(2.0%), 4(1.33%) respectively. Conclusion: our study, we found that 4.00% subjects have antibodies. anti-E, anti-C, anti-Kell, are part system. autoantibodies IgG.