The GeneXpert Test for The Diagnosis of Childhood Pulmonary Tuberculosis in Suspected Cases: Study in a Tertiary Care Hospital in Bangladesh

• DOI: 10.36348/merjms.2024.v04i06.004
• Publication Date: 2024-11-19T10:53:34Z
• Authors: Dr. K. Qamruzzaman; Dr. S. Ahsan Tauhid; Dr. Md. A. Rahman; Dr. Sk Sadek Ali; Dr. Md. M. Islam; Dr. M. Chowdhury; Dr. M. Tabassum; Dr. M. Monir Hossain; Dr. Md. M. Rahman; Dr. T. Sultana
• Keywords: GeneXpert MTB/RIF; Tertiary care

Background: Pulmonary tuberculosis (PTB) remains a significant health issue in children. Early and accurate diagnosis is critical but challenging, The GeneXpert test, rapid molecular diagnostic tool, has improved TB detection by identifying Mycobacterium resistance to rifampicin within hours. Aim of the study: This study aimed assess role test diagnosing pulmonary clinically suspected pediatric cases. Methods: cross-sectional observational was conducted department pediatrics, Sir Salimullah Medical College Mitford Hospital, Dhaka, Bangladesh from March 2021 August 2022. In this study, 280 cases, all under 12 years old suspected, were enrolled using purposive sampling. Diagnostic tests, including chest X-ray, Mantoux microscopy sputum or gastric aspirate, GeneXpert, validate clinical diagnoses. Data analysis carried out SPSS version 23.0 program. Results: our demonstrated high sensitivity (96.79%), effectively true positives, had moderate specificity (51.61%), resulting more false positives. positive predictive value 71.56%, negative 92.75%, indicating higher accuracy correctly negatives. Overall, achieved an 76.79%, showing it reliably determined disease status most Conclusion: effective procedure for detecting patients. It shows presumptive