The prevalence and antimicrobial susceptibility of circulating S. pneumoniae serotypes in adult population in Russia (epidemiological study «SPECTRUM»)

• DOI: 10.36488/cmac.2021.2.127-137
• Publication Date: 2021-09-10T07:14:37Z
• Authors: Roman S. Kozlov; Alexander A. Mura...; Aida N. Chagaryan; Nataly V. Ivanchik; Anastasia A. Kurkova; Alexey Yu. Kuzmenkov; Ivan V. Trushin; Marina V. Sukhoru...
• Keywords: 0303 health sciences; acute otitis media; Infectious and parasitic diseases; RC109-216; invasive pneumococcal disease; Microbiology; QR1-502; 3. Good health; healthy carriers; 03 medical and health sciences; serotypes; s pneumoniae; antimicrobial resistance; communityacquired pneumonia

Objective. To estimate prevalence and antimicrobial susceptibility of circulated S. pneumoniae serotypes in adult population different regions the Russian Federation. Materials Methods. A total 500 isolates obtained from patients with invasive pneumococcal disease (IPD), community-acquired pneumonia (CAP), sinusitis/acute otitis media (AOM) healthy carriers 29 centers were included study 01 June 2019 to 15 January 2020. Re-identification, typing using real-time PCR 27 primer pairs testing performed central laboratory by standardized methods. Results. Among 50 IPD, following detected: 3 (20.0%), 23F (10.0%), 6ABCD (8.0%), 19F (6.0%), 12ABF, 4, 7AF, 8, 9NL, 9VA, 15B (4.0% each), 1, 10A, 11AD, 14, 15AF, 18ABCF, 22AF, 33F/33A/37 (2.0% each). PCV-13 PPV-23 covered 62.0% 86.0% those serotypes, respectively. 357 CAP, (12.3%), (11.5%), (10.1%), (5.9%), 14 (5.3%), 22AF (5.0%), 11AD (4.8%), 9NL (3.4%), 15AF (2.8%), 9VA (2.2%), 18ABCF (2.0%), 19A (1.7%), 12ABF (1.4%), 17F (0.8%), 16, 33F/33A/37, 7AF 8 (0.6% 10A 4 (0,3% each); not specified due protocol limitations for 106 (29.8%) isolates. 51.9% 68.7% In sinusitis/AOM (n = 48), were: (18.8%), (16.7%), (12.5%), (6.3%), (4.2%), (2.1% 75.0% 83.3% nasopharyngeal 45), (24.4%), (17.8%), (13.3%), (8.9%), (6.7%), (2.2% 71.1% 91.1% Serotypes 19F, frequently resistant three antibiotics – penicillin, erythromycin, tetracycline. Resistance respiratory quinolones was very low (0.7%) detected among only. The majority non-vaccine did have substantial resistance problems. Conclusions. Despite relatively number all but CAP group protocol, results our support use vaccines (PPV-23 PCV-13) population, some advantages over PCV-13.