Spectrum of sensitization to aeroallergens as one of the risk factors for uncontrolled severe asthma

• DOI: 10.36691/rja15043
• Publication Date: 2023-10-05T08:20:37Z
• Authors: Yana I. Kozlova; Nikolay Y. Vasiliev; Ekaterina V. Frolova; Alexandra E. Uche...; Larisa V. Filippova; Natalya V. Vasilyeva
• Keywords: 03 medical and health sciences; 0302 clinical medicine; 3. Good health

BACKGROUND: Asthma is considered one of the urgent medical and social problems XXI century. In recent years, not only an increase in incidence, but also prevalence severe forms asthma has been noted all countries world. The effect sensitization spectrum on severity level control studied enough.
 AIM: Evaluate importance to aeroallergens patients as indicators for disease exacerbation risk.
 MATERIALS AND METHODS: Single-center cross-sectional study at North-Western State Medical University n.a. I.I. Mechnikov. Examined 93 patients. Analysis covered demographic traits, comorbidities, hereditary history, living conditions, exacerbations, past-year hospitalizations, medications, spirometry, specific IgE presence 10 aeroallergens.
 RESULTS: Aspergillus fumigatus notably impacted control. Disease risk was 8.4 times higher with A. sensitization. Multivariate logistic regression revealed (4.79), fixed obstruction (6.2), systemic steroids use (5.85), indoor mold exposure (4.45), familial history (2.53).
 CONCLUSION: significantly influences course control, worsening prognosis. Targeted examination measuring sIgE levels common necessary identify obstacles. results were previously reported All-Russian Congress Microbiology, Clinical Mycology Immunology published form abstracts journal Problems mycology, 2022, Vol. 24, No 2.