Primary Lymphoepithelioma-Like Carcinoma of Ocular Adnexa: Clinicopathologic Features and Treatment

• DOI: 10.3747/co.20.1289
• Publication Date: 2013-04-04T22:12:56Z
• Authors: B. Qiu; Y.B. Lin; Q.Q. Cai; Y.M. Hu; D.F. Wang; Z.D. Lin; Y. Liang
• Keywords: Lymphoepithelioma-like carcinoma; Primary (astronomy)

Background and Methods: Lymphoepithelioma-like carcinoma (LELC) is a rare malignancy in ocular adnexa. Here, we report 4 patients with LELC review 11 reported the literature. Clinical profiles, association Epstein–Barr virus (EBC), treatment, outcomes are analyzed. Results: Lacrimal glands lacrimal drainage system, eyelid, conjunctiva potential primary sites for LELC. The tumours characterized histologically by nests of undifferentiated malignant cells surrounded lymphoid infiltrates. Infection EBC was confirmed adnexa, that seemed to be restricted Asian populations. Results from our centre uniformly showed expression EBC-encoded small rnas tumour, locally recurrent metastatic lymph nodes. This disease had tendency relapse regionally. Postoperative radiotherapy seems improve disease-free survival. Tumours appear sensitive chemotherapy based on cisplatin 5-fluorouracil. At centre, 3 were still living at 22, 33, 76 months after surgery. One patient died distant metastasis survival 38 months. Conclusions: heterogenous entity among adnexal malignancies. Multimodality treatment provides better chance Further investigation required achieve understanding biologic behavior this its optimal treatment.