Autoimmune gastritis presenting as iron deficiency anemia in childhood

• DOI: 10.3748/wjg.v20.i42.15780
• Publication Date: 2014-11-14T03:34:16Z
• Authors: Cristina Gonçalves
• Keywords: Autoimmune Gastritis; pernicious anemia; Autoimmune thyroiditis

AIM:To characterize clinical, laboratorial, and histological profile of pediatric autoimmune gastritis in the setting unexplained iron deficiency anemia investigation. METHODS:A descriptive, observational study including patients with a diagnosis (positive parietal cell antibody gastric corpus atrophy) established 6 year period (2006-2011) refractory (refractoriness to oral therapy for at least mo requirement intravenous therapy) investigation, after exclusion other potentially contributing causes anemia.Helicobacter pylori (H.pylori ) infection anti-secretory were also excluded.Data retrospectively collected from clinical files, including: demographic data (age, gender, ethnic background), past medical history, gastrointestinal symptoms, familial laboratorial evaluation (Hb, serum ferritin, gastrin, pepsinogen Ⅰ/ Ⅱ, B12 vitamin, intrinsic factor autoantibodies, thyroid anti-transglutaminase antibodies), endoscopic findings (HE, Periodic Acid-Schiff/Alcian blue, chromogranin A immunochemistry analysis CD3, CD20 CD68).Descriptive statistical was performed (mean, median, standard deviation).