Autoimmune hepatitis and anti-tumor necrosis factor alpha therapy: A single center report of 8 cases

• DOI: 10.3748/wjg.v21.i24.7584
• Publication Date: 2015-07-01T03:05:01Z
• Authors: Susana Rodrigues
• Keywords: Autoimmune Hepatitis; Single Center

This article describes cases of anti-tumor necrosis factor (TNF)-α-induced autoimmune hepatitis and evaluates the outcome these patients in relation to their immunosuppressive strategy.A retrospective analysis medical records was performed our center, order detect (AIH) associated with anti-TNF biologic agents.We describe analyze eight AIH following therapy, 7 infliximab 1 adalimumab.A distinction should be made between induction autoimmunity clinically evident disease.Liver biopsy is useful detecting role TNF-α antagonist development AIH.The lack relapse after discontinuing therapy favors, as this case series, an immune-mediated drug reaction most have a treatment suspended.Although related rare, baseline immunological panel along liver function tests all CASE REPORT 7584