Medication beliefs predict medication adherence in ambulatory patients with decompensated cirrhosis

• DOI: 10.3748/wjg.v23.i40.7321
• Publication Date: 2017-10-29T11:51:36Z
• Authors: Kelly L Hayward; Patricia C Valery; Jennifer H Martin; Antara Karmakar; Preya J Patel; Leigh U Horsfall; Caroline J Tallis; Katherine A Stuart; Penny L Wright; David D Smith; Katharine M Irvine; Elizabeth E Powell; W Neil Cottrell
• Keywords: Liver-Disease; Liver Cirrhosis; Male; Health Knowledge, Attitudes, Practice; liver cirrhosis; Culture; 610; Observational Study; United-States; Heart-Failure; Medication Adherence; Quality-Of-Life; 03 medical and health sciences; 0302 clinical medicine; Humans; 2715 Gastroenterology; Mortality; Drug Classes; Illness; Aged; illness perceptions; Questionnaire; Self-Management; Hepatic-Encephalopathy; Middle Aged; 3. Good health; Cross-Sectional Studies; quality of life; medication adherence; Quality of Life; Female; Perception; Self Report; medication beliefs

To investigate the impact of medication beliefs, illness perceptions and quality life on adherence in people with decompensated cirrhosis.One hundred adults cirrhosis completed a structured questionnaire when they attended for routine outpatient hepatology review. Measures self-reported (Morisky Medication Adherence Scale), beliefs surrounding medications (Beliefs about Medicines Questionnaire), medicines (Brief Illness Perception (Chronic Liver Disease Questionnaire) were examined. Clinical data obtained via patient history review medical records. Least absolute shrinkage selection operator stepwise backwards regression techniques used to construct multivariable logistic model. Statistical significance was set at alpha = 0.05.Medication "High" 42% participants, "Medium" 37%, "Low" 21%. Compared patients adherence, those or more likely report difficulty affording their (P < 0.001), lower perception treatment helpfulness 0.003) stronger concerns relative necessity 0.003). People also experienced greater symptom burden poorer life, including frequent abdominal pain 0.023), shortness breath 0.030), emotional disturbances 0.050). Multivariable analysis identified having (Necessity-Concerns Differential ≤ 5, OR 3.66, 95%CI: 1.18-11.40) (shortness score 3, 3.87, 1.22-12.25) as independent predictors "Low"adherence.The association between strong doubting should be explored further given clinical relevance.