Stage at diagnosis of colorectal cancer through diagnostic route: Who should be screened?

• DOI: 10.3748/wjg.v30.i10.1368
• Publication Date: 2024-03-14T12:50:24Z
• Authors: Nobukazu Agatsuma; Takahiro Utsumi; Yoshitaka Nishikawa; Takahiro Horimatsu; Takeshi Seta; Yukitaka Yamashita; Yukari Tanaka; Takahiro Inoue; Yuki Nakanishi; Takahiro Shimizu; Mikako Ohno; Akane Fukushima; Takeo Nakayama; Hiroshi Seno
• Keywords: Cancer screening; Univariate analysis

BACKGROUND Colorectal cancer (CRC) is a global health concern, with advanced-stage diagnoses contributing to poor prognoses. The efficacy of CRC screening has been well-established; nevertheless, significant proportion patients remain unscreened, > 70% cases diagnosed outside screening. Although identifying specific subgroups for whom should be particularly recommended crucial owing limited resources, the association between diagnostic routes and identification these less appreciated. In Japanese registry, groups discovered are primarily categorized into those comorbidities found during hospital visits CRC-related symptoms. AIM To clarify stage at diagnosis based on routes. METHODS We conducted retrospective observational study using registry January 2016 December 2019 two hospitals. were classified three groups: Cancer screening, follow-up, symptomatic. early-stage was defined as Stages 0 or I. Multivariate univariate logistic regressions exploited determine odds in symptomatic groups, referencing follow-up group. adjusted covariates age, sex, tumor location. RESULTS Of 2083 patients, 715 (34.4%), 1064 (51.1%), 304 (14.6%) belonged symptomatic, respectively. Among CRCs an early 57.3% (410 715), 23.9% (254 1064), 59.5% (181 304) group exhibited lower likelihood than [P < 0.001, ratio (aOR), 0.23; 95% confidence interval (95%CI): 0.19-0.29]. similar (P = 0.493, aOR vs 1.11; 95%CI 0.82-1.49). CONCLUSION detected earlier, recommended, without periodical comorbidities.