Selective hippocampal lesions in rats do not affect retrieval processes promoted by prior cuing with the conditioned stimulus or the context

• DOI: 10.3758/bf03327112
• Publication Date: 2022-01-21T16:57:20Z
• Authors: Pascale Gisquet-V...; Françoise Schenk
• Keywords: Engram; Stimulus (psychology)

Following partial training in an avoidance brightness discrimination task a Y-maze, the retention performance can be enhanced by pretest exposure to various features (prior cuing). The effectiveness of these cues may vary as function length interval. These results demonstrate that prior cuing promotes retrieval memory trace and is submitted long-lasting time-dependent reorganization. present experiments were designed examine involvement hippocampal formation processes promoted cuing. Rats with bilateral ibotenic acid lesions sham-operated rats postoperatively trained task. Retrieval not affected lesions: After 1-day training-to-test interval (TTI), both conditions demonstrated dramatic improvement following conditioned stimulus (CS; Experiment 1). 21-day TTI, CS was no longer effective, experimental context (Experiment 2). In contrast, when lesioned tested radial arm maze task, they showed severely impaired performance, demonstrating on behavior. damage hippocampus does disrupt promotion particular, did prevent from being able relate initial episode. fact also changes certain suggests this structure involved long-term maturation evidenced