expression of mica b protein in esophageal cancer and its clinical significance

• DOI: 10.3760/cma.j.issn.0253-3766.2012.10.006
• Publication Date: 2012-10-01
• Authors: Fang-fang Gao; Guiju Liu; Guang-ying Yang; Jiazhuan Mei; Jizhi Zhao
• Keywords: Adult; Aged, 80 and over; Male; Esophageal Neoplasms; Histocompatibility Antigens Class I; Biomarkers, Tumor; Humans; Female; Middle Aged; Neoplasm Grading; Immunohistochemistry; Aged; Up-Regulation

To explore the expression of MICA/B in human esophageal cancer, and to analyze its correlation with clinicopathological features.The expression of MICA/B in 40 cases of esophagus carcinoma and corresponding normal esophageal mucosa tissues were examined by immunohistochemistry.The positive rate of expression of MICA/B protein in the esophageal carcinoma was 75.0% (30/40), and that in the corresponding normal esophageal mucosa was 0 (0/40). Up-regulation of MICA/B expression was found in the esophageal carcinomas. The expression of MICA/B was related with histological grade of the esophageal carcinoma (P = 0.012).MICA/B protein plays an important role in the esophageal carcinogenesis, and my become a useful molecular marker for the diagnosis of esophageal carcinoma.