[Analysis of prevalence and related factors of osteoporosis in retired population based on Dongfeng-Tongji Cohort].

• DOI: 10.3760/cma.j.issn.0253-9624.2017.10.011
• Publication Date: 2017-10-06
• Authors: Han Yan; X Z Liu; Y Z Zhang; Miao He; T C Wu
• Keywords: Cohort Studies; Male; China; Retirement; Risk Factors; Prevalence; Humans; Osteoporosis; Female; Middle Aged; Aged

Objective: To investigate the prevalence and related factors of osteoporosis among retired population in Dongfeng-Tongji cohort. Methods: 27 009 participants were recruited from Dongfeng Motor Corporation Hubei Province 2008 followed up April to October 2013. newly also recruited. Data collected by using questionnaire, physical examination, serum hepatase detection bone densitometry. Totally, 30 916 included for data analysis after excluding with severe metabolic diseases, taking hormone drugs, incomplete follow-up who under 45 years old. Age-standardized was calculated according 2010 Sixth National Population Census. Multivariate logistic regression applied explore associated osteoporosis. Results: Prevalence 42.3% (13 083/30 916) age standardized 40.7%: 35.0% (4 854/13 878) 34.8% males; 48.3% (8 229/17 038) 47.1% females. Significantly both males females included: older (male: OR=1.67, 95%CI: 1.40-1.99; female:OR=3.34, 2.70-4.13), lower BMI OR=1.70, 1.40-2.06; female: OR=1.27, 1.04-1.53), exercise OR=0.69, 0.61-0.78; OR=0.87, 0.80-0.96), abnormal elevated alkaline phosphatase (ALP) OR=1.12, 1.01-1.24; OR=1.15, 1.06-1.25), γ-glutamyltransferase (γ-GT) OR=1.16, 1.02-1.30; OR=1.13, 1.03-1.24) aspartate transaminase/alanine aminotransferase (AST/ALT) 1.05-1.25; OR=1.28, 1.19-1.38). Smoking (OR=1.27, 1.07-1.39) drinking (OR=1.11, 1.08-1.16) while menopausal (OR=1.67, 1.47-1.89) There positive dose-response correlation relationships levels ALP, γ-GT AST/ALT (all P values<0.05). Conclusion: Osteoporosis relatively common In addition known such as age, exercise, osteoporosis.目的： 分析东风-同济队列中离退休人群骨质疏松症患病率及其相关因素。 方法： 2008年在湖北省招募27 009名东风汽车公司离、退休职工，2013年4—10月进行第1次随访，同时纳入新的退休人群。所有研究对象均进行了问卷调查、体格检查、血清肝酶检测和骨密度测定。排除患有严重的骨代谢疾病、服用激素类药物、年龄<45周岁及资料缺失者，共有30 916名对象纳入本研究。应用2010年全国第六次人口普查资料对患病率进行年龄标化，并采用多因素logistic回归模型分析骨质疏松症的相关因素。 结果： 骨质疏松症患病率为42.3% 916)，标化患病率为40.7%，其中男性患病率为35.0% 878)，标化患病率为34.8%，女性患病率为48.3% 038)，标化患病率为47.1%。男、女性骨质疏松症共同的相关因素包括：高龄（男性：OR=1.67, 1.40~1.99；女性：OR=3.34, 2.70~4.13）、低BMI（男性：OR=1.70, 1.40~2.06；女性：OR=1.27, 1.04~1.53）、锻炼（男性：OR=0.69, 0.61~0.78；女性：OR=0.87, 0.80~0.96）、血清碱性磷酸酶（ALP）升高（男性：OR=1.12, 1.01~1.24；女性：OR=1.15, 1.06~1.25）、γ-谷氨酰转肽酶（γ-GT）升高（男性：OR=1.16, 1.02~1.30；女性：OR=1.13, 1.03~1.24）和谷草转氨酶（AST）/谷丙转氨酶（ALT）比值升高（男性：OR=1.15, 1.05~1.25；女性：OR=1.28, 1.19~1.38）。男性中特有的相关因素包括吸烟（OR=1.27, 1.07~1.39）和饮酒（OR=1.11, 1.08~1.16），而女性为绝经（OR=1.67, 1.47~1.89）。血清ALP、γ-GT、ASTALT水平与骨质疏松症患病风险呈剂量-反应关系（P值均<0.05）。 结论： 东风-同济队列退休人群骨质疏松症患病率较高，除高龄、低BMI、锻炼等已知相关因素外，血清ALP水平、γ-GT水平和AST/ALT比值升高也与骨质疏松症相关。.