[Analysis of correlation between serum fatty acid profile and cognitive impairment in the elderly].

• DOI: 10.3760/cma.j.issn.0253-9624.2018.06.013
• Publication Date: 2018-06-06
• Authors: Shuang Song; Hui Wang; Shanshan Jia; Qingqing Man; Bin Qin; Jian Zhang
• Keywords: High-density lipoprotein

Objective: To explore the relationship between cognitive impairment and serum fatty acid profile. Methods: Participants aged ≥60 years were selected from 3 communities in Shijiazhuang 2015. The questionnaire was performed to collect basic information. And Montreal Cognitive Assessment applied for evaluation of impairment. Blood lipid parameters profiles analyzed all subjects. A total 529 subjects finally included this research. Multivariate ordinal logistic model used analyze profile Results: Normal, mild moderate accounted 41.2% (n=218), 51.4% (n=272) 7.4% (n=39) respectively. With control age, gender, education, cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL-C), high (HDL-C), OR (95%CI) eicosenoic acid, nervonic ratio n-3 n-6 polyunsaturated (n-3/n-6) 1.06 (1.01-1.10), 0.93 (0.91-0.96), 0.17 (0.04-0.73). Conclusion: risk decreased with raise concentration n-3/n-6, increased concentration.目的： 探讨血清脂肪酸谱与老年认知障碍的关系。 方法： 于2015年在石家庄3个社区招募60岁以上老年人，进行基本情况问卷调查，采用蒙特利尔认知评估量表评估认知功能水平，检测血清生化指标，并分析血清脂肪酸谱。最终有效样本量为529名。采用多因素有序logistic回归模型分析脂肪酸谱与认知障碍的关系。 结果： 认知功能正常、轻度认知障碍、中度认知障碍者分别占41.2%（218名）、51.4%（272例）、7.4%（39例）。调整年龄、性别、教育程度、总胆固醇、甘油三酯、HDL-C、LDL-C后，二十烯酸、神经酸及n-3多不饱和脂肪酸与n-6多不饱和脂肪酸的比值（n-3/n-6）与老年人认知受损风险OR(95%CI)值分别为1.06（1.02~1.10）、0.94（0.91~0.97）及0.17（0.04~0.73）。 结论： 老年人认知受损风险随血清神经酸及n-3/n-6的升高而降低，并随二十烯酸水平升高而上升。.