Influence of hyperbaric oxygen on the early-stage osseointegration of porous implant in a rabbit model of necrosis of femoral head induced by steroid

• DOI: 10.3760/cma.j.issn.0254-1424.2010.02.004
• Publication Date: 2010-02-25
• Authors: Jijun Zhao; Dehong Feng; Cheng Li
• Keywords: Avascular Necrosis

Objective To observe the effect of hyperbaric oxygen (HBO) therapy on bone ingrowth into porous implant in a rabbit model avascular necrosis femoral head induced by dexamethasone. Methods Thirty-two New Zealand rabbits were subject to intramuscular injection dexamethasone twice week for 8 weeks.Then,rabbits divided 4 groups:control group,HBO group,recombinant human morphogenetie protein-2 (rhBMP-2) group and HBO + rhBMP-2 randomly.The femurs control implanted with bare implants,while implants collagen compounded rhBMP-2.Control treated without HBO;HBO HBO.All sacrificed at 12th weeks after operation.All samples right used making hard tissue slices,while all left biomechanics test. Results The oaseointegration rate:HBO ＞ group.The difference between was not statistically significant (P＞0.05).Differences among other groups (P＜0.05).New group.Differences every two (P＜0.05).The results pull out test showed that anti-shearing force greater than group,the differences (P ＜0.05).Anti-shearing little group,but there no 0.05).Anti-shearing significantly (P＜0.05). Conclusions can improve osseointegration rate implant,promote new implant,enhance integration strength implant.HBO have cooperative effect,but carrier prevent implant.

Key words: Hyperbaric oxygen; Hormone; Necrosis head; Porous implant; Osseointegration