The effects of intravenous immunoglobulin on the expression of IgGFc receptor and TLR4 in children with acute Kawasaki disease

• DOI: 10.3760/cma.j.issn.0254-5101.2013.03.009
• Publication Date: 2013-03-31
• Authors: Xiuli Tian; Chengrong Li; Qiu Li; Guobing Wang; Jun Yang
• Keywords: Monocyte

Objective To investigate the effects of intravenous immunoglobulin (IVIG) on expression FcγR Ⅱ b and Toll-like receptor 4 (TLR4) in children with Kawasaki disease (KD).Methods 25 KD 15 healthy controls were enrolled this study.The levels TLR4 monocytes assessed by flow cytometry.Real-time PCR was performed to detect transcription b,TLR4 signaling molecules(MyD88,TRAF-6,TAK1) cytokines(IL-1β,IL-6,TNF-α) monocytes.The concentrations TNF-α plasma determined enzyme-linked immunosorbent assay (ELISA).Results (1) Compared controls,the molecules patients significantly up-regulated but decreased after treatment IVIG (P＜0.05).(2)The Ⅱb from higher than those controls,and IVIG(P＜0.05).(3) The cytokine factor such as IL-1β,IL-6 found be (P＜0.05) ; elevated during acute (P＜0.05).(4)There correlations follow between cytokine,TLR4 (P ＜0.05).Conclusion can up regulate down which might inhibit inflammatory response.

Key words: Fc gamma receptors; Kawasaki disease; Toll-like 4; Cytokine