Clinical and molecular characteristics of invasive community-acquired methicillin-resistant Staphylococcus aureus infection in Chinese neonates

• DOI: 10.3760/cma.j.issn.0254-5101.2017.07.013
• Publication Date: 2017-07-31
• Authors: Wenjing Geng; Fang Dong; Jingwen Weng; Shixiao Dong; Fei Jin; Xuzhuang Shen; Yujie Qi
• Keywords: SCCmec; Multilocus sequence typing; Agar dilution

Objective To analyze the clinical and molecular features of community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infection in neonates to investigate their antibiotic resistance profiles.

Methods A total 35 invasive CA-MRSA strains were collected from six hospitals 2014. Multilocus sequence typing (MLST), staphylococcal cassette chromosome mec (SCCmec) spa used these isolated strains. In vitro susceptibilities those 15 antibiotics analyzed by using agar dilution method.

Results Up 88.6% patients late-onset septicemia (24, 68.5%) was most common among cases. A 16 (45.7%) suffered complications. Caesarean section premature birth risk factors for infection. ST59-MRSA-SCCmecⅣa-t437 (14, 40%) predominant clone, followed ST59-MRSA-SCCmecⅤ-t437 (13, 37.1%). The incidence severe complications caused higher than that (P<0.05). Up 85.7% multidrug-resistant strains.

Conclusion This study shows neonatal infections mainly result are often accompanied involve multiple organs. Multidrug-resistant prevalent neonates. is clone causing infection.

Key words: CA-MRSA; Neonate; Invasive