Progress in pathogenesis of adverse pregnancy outcomes induced by group B Streptococcus

• DOI: 10.3760/cma.j.issn.0254-5101.2018.09.012
• Publication Date: 2018-09-30
• Authors: Yuqin Zang; Chen Wang; Wenyan Tian
• Keywords: Pathogenesis; Group B; Neonatal Infection

Group B Streptococcus (GBS) is a leading infectious cause of adverse pregnancy outcomes such as preterm birth. GBS colonizes the vagina during and can ascend into uterus then infect fetus. It encodes series virulence factors adhesion invasion factors, hemolytic pigments hyaluronidase, which are important to vaginal colonization immune evasion. Immune responses release multiple inflammatory mediators, premature rupture membranes, birth fetal injury. This paper reviews pathogenesis ascending infection causing outcomes.

Key words: Group Streptococcus; Vaginal colonization; Ascending infection; Adverse outcome; Pathogenesis