Relationships between differences in tumorigenicity and immunogenetic backgrounds of nude mice

• DOI: 10.3760/cma.j.issn.0254-5101.2018.11.006
• Publication Date: 2018-11-30
• Authors: Jie Wei; Hong Wang; Jinping Fan; Tao Fan; Chunnan Liang; Liu Zuo-min
• Keywords: Nude mouse

Objective To study the relationships between differences in tumorigenicity and immunogenetic backgrounds of nude mice.

Methods According to Chinese Pharmacopoeia, positive negative groups were set up both Laboratory A B with ten mice each group. Organ tissues collected for clinicopathological analysis. Blood samples detected using flow cytometry. DNA was extracted analyzed 23 STR markers.

Results The group invalid (7/10 tumor formation). The two laboratories showed no significant difference results pathological analysis, but had CD25, CD8, CD4, Th1 Th2. There 13 18 polymorphic sites respectively found B. Further analysis non-tumor-bearing revealed that Th2, D3Mit29 D5Mit48 specific indexes.

Conclusion Differences might be related diversity mice.

Key words: Nude mice; Tumorigenicity; Immune; Genetics