IL-10 promotes Chlamydia muridarum infection in mice through inhibiting IFN-γ and IL-2 expression

• DOI: 10.3760/cma.j.issn.0254-5101.2019.02.009
• Publication Date: 2019-02-28
• Authors: Qing‐zhi He; Mengting He; Xin Wang; Xiao‐Qing Luo; Yimou Wu; Guangming Zhong
• Keywords: Sex organ; Chlamydia trachomatis infection; Hydrosalpinx; Immunofluorescence

Objective To study the possible molecular mechanism of IL-10 in promoting Chlamydia muridarum infection mice.

Methods C57BL/6 wild-type and gene knockout (IL-10-/-) mice were infected with muridarum. Indirect immunofluorescence assay was used to detect growth intestinal genital tracts. The severity diseases assessed by hydrosalpinx scoring. Expression IFN-γ IL-2 blood measured ELISA.

Results Compared group, clearance tracts IL-10-/- significantly faster, expression increased significantly. In addition, showed more serious hydrosalpinx.

Conclusions IL-10 delays trachomatis promotes through inhibiting IL-2, which aggravates hydrosalpinx.

Key words: Chlamydia trachomatis; IL-10; Cytokine; Immunity