Potential biomarkers predicting risk of pulmonary hypertension in congenital heart disease: the role of homocysteine and hydrogen sulfide

• DOI: 10.3760/cma.j.issn.0366-6999.20132694
• Publication Date: 2024-01-16T19:01:22Z
• Authors: Ling Sun; Shuo Sun; Yufen Li; Wei Pan; Yumei Xie; Shushui Wang; Zhiwei Zhang
• Keywords: Heart Defects, Congenital; Male; Child, Preschool; Hypertension, Pulmonary; Infant, Newborn; Humans; Infant; Female; Hydrogen Sulfide; Prospective Studies; Child; Homocysteine; Biomarkers

Background Pulmonary hypertension (PH) is a common complication of congenital heart disease (CHD). Although risk stratification vital for prognosis and therapeutic guidance, the need understanding role novel biomarkers cannot be overlooked. The aim present study was to investigate changes homocysteine hydrogen sulfide levels find potential early detection treatment. Methods Between September 2012 April 2013, we prospectively collected data on 158 pediatric patients with left right shunt CHD at our institution. Standard catheterizations were performed in all cases. Seventy-seven cases associated PH. detected fluorescence polarization immunoassay sensitive silver-sulphur electrode, respectively. Enzyme-linked immunosorbent assay used determine expression methylenetetrahydrofolate reductase (MTHFR), cystathionine β-synthase (CBS), gamma-lyase (CSE). Radioimmunoassays obtain folic acid vitamin B12 levels. Results difference homocysteine, acid, B12, sulfide, as well MTHFR CSE between PH without statistically significant (all P <0.05). Homocysteine had best sensitivity specificity predict ( <0.001). Subgroup analysis showed that dynamic obstructive significantly different Based ROC curve, =0.032), while most =0.008). Conclusions Increased decreased negatively correlated CHD. underlying mechanism involved along deficiency. are