Suture-reinforced polydioxanone-elastin for tissue engineering of small-diameter vessels: a feasibility study

• DOI: 10.3760/cma.j.issn.1005-054x.2010.02.024
• Publication Date: 2010-04-10
• Authors: Guang Chen; Yong-jun Rui; Kuishui Shou; Haifeng Shi; Gang Zhao
• Keywords: Polydioxanone; Biomechanics

Objective To investigate the feasibility of constructing sutuze-reinforced polydioxanone(PDS)multilayer small-caliber artificial scaffolds and determine its biomechanical properties.Methods 7-0PDS fibers were woven into a stent with 4 mm inner diameter.The influence different weaving angle knitting structure on mechanical properties investigated.Multilayer constructed using preparecl PDS as middle elasticity layer covering it small intestinal submucosa(SIS).To reinforce scaffold,the outer two lavers continuously sutured 8-0 suture perpendicular to longitudinal axis.The scaffold was coated With collagen sponge which added 10%chondroitin sulfate(CS).The such burst strength,tensile strength compliance tested compared those canine carotid artery.Results 65-degree chosen construct diameter 3 5 cm length.These had(43.50±8.30)kPa strength,(19.10±1.56)N tensile strength,(42.88±3.16)% strain ratio and(5.96±0.87)%/100 Hg radial compliance.Conclusion The multilayer have satisfactory that meet requirements for in vivo implantation tissue engineered blood vessel.

Key words: Tissue engineering; Blood vessels; Biomechanics; Polydioxanone