Quantitative radiological evaluation of interaction of lumbar vertebral bone marrow fat, bone mineral density and age

• DOI: 10.3760/cma.j.issn.1005-1201.2017.10.010
• Publication Date: 2017-10-10
• Authors: Yong Zhang; Xiaoguang Cheng; Aihong Yu; Ling Wang; Chenxin Zhang; Wei Zhao; Yangyang Duanmu
• Keywords: Vertebra

Objective To explore the change patterns in lumbar vertebral bone marrow fat content with age, analyze interactions between content, mineral density (BMD), and compare difference of males females same age groups.

Methods According to statistical sample size requirements that minimum each group was 18, thus, we prospectively recruited healthy volunteers who met inclusion criteria. Among them, there were 139 females, range 21-70 years old. According patients divided into 1 (21-30-yr), 2 (31-40-yr), 3 (41-50-yr), 4 (51-60-yr), 5 (61-70-yr). Quantitative computed tomography (QCT) used measure BMD, MR mDIXON-Quant technique L3 vertebra. We compared BMD different groups using one-way ANOVA, t-test. Correlation analysis conducted age.

Results Lumbar generally increasing age. There significant differences at (male, F=13.598, P=0.000; female, F=73.419, P=0.000). Before 50 years, lower than one males, a [females, (29.7±7.1) %- (36.1±6.6) %, (34.1±8.4) (39.9±5.9) %;21-30-yr, t=1.984, P=0.053;31-40-yr, t=5.699, P=0.000;41-50-yr, t=2.017, P=0.050]. Females older had higher (48.3±8.8) (52.5±8.2) (45.5±8.1) (46.2±7.4) %;51-60-yr, t=-0.914, P=0.365;61-70-yr, t=-3.400, P=0.001]. For positively correlated (r=0.527, P<0.05), negatively (r=-0.730, adjusted for r=-0.584, P<0.05). (r=0.761, (r=-0.809, r=-0.473, P<0.05).

Conclusions Lumbar Bone females.

Key words: Lumbar vertebrae; Bone density; Age distribution; Bone fat; Imaging assessment