Progress in the key enzymes in tumor lipid metabolism

• DOI: 10.3760/cma.j.issn.1006-9801.2016.11.020
• Publication Date: 2016-11-28
• Authors: Long Yuan; Pan Zhao; Wenhua Zhu
• Keywords: Fatty acid synthesis; Fatty Acid Metabolism

Lipid metabolism plays an important role in the occurrence and development of tumor cells. The normal cells provide energy through lipids circulation system, while their own de novo synthesis. This abnormal lipid not only supplies for to rapidly proliferate, but also related are involved molecular signal pathways tumor. Increasing studies have found that there is a close relationship between Some key enzymes process metabolism, such as fatty acid synthase (FASN) stearoyl-coenzyme A desaturase 1(SCD1), become research hotspot. expressions these significantly higher tissues than those tissue, which indicates expected new targets diagnosis therapy. review mainly describes development.

Key words: Lipid metabolism; Fatty synthase; Stearoyl-coenzyme destatu rase